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SKP2 and OTUD1 govern non-proteolytic ubiquitination of YAP that promotes YAP nuclear localization and activity
Dysregulation of signaling pathways that control organ size, such as the AKT-mTOR and Hippo-YAP pathways, often leads to tumorigenesis and metastasis. The Hippo pathway effector YAP is a transcriptional co-activator overexpressed or activated in human tumors. Accumulating evidence has demonstrated t...
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| Pubblicato in: | Cell Stress |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Shared Science Publishers OG
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6558927/ https://ncbi.nlm.nih.gov/pubmed/31225491 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15698/cst2018.09.153 |
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