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Structural insights into substrate recognition by the SOCS2 E3 ubiquitin ligase
The suppressor of cytokine signaling 2 (SOCS2) acts as substrate recognition subunit of a Cullin5 E3 ubiquitin ligase complex. SOCS2 binds to phosphotyrosine-modified epitopes as degrons for ubiquitination and proteasomal degradation, yet the molecular basis of substrate recognition has remained elu...
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| Veröffentlicht in: | Nat Commun |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group UK
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6557900/ https://ncbi.nlm.nih.gov/pubmed/31182716 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10190-4 |
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