C53: A Novel Particulate Guanylyl Cyclase B Receptor Activator That Has Sustained Activity In Vivo With Anti-Fibrotic Actions in Human Cardiac and Renal Fibroblasts

The native particulate guanylyl cyclase B receptor (pGC-B) activator, C-type natriuretic peptide (CNP), induces anti-remodeling actions in the heart and kidney through the generation of the second messenger 3’,5’ cyclic guanosine monophosphate (cGMP). Indeed fibrotic remodeling, particularly in card...

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Detalhes bibliográficos
Publicado no:J Mol Cell Cardiol
Main Authors: Chen, Yang, Zheng, Ye, Iyer, Seethalakshmi R., Harders, Gerald E., Pan, Shuchong, Chen, Horng H., Ichiki, Tomoko, Burnett, John C., Sangaralingham, S. Jeson
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6557127/
https://ncbi.nlm.nih.gov/pubmed/30954448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2019.03.024
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