Modulation of temozolomide dose differentially affects T-cell response to immune checkpoint inhibition

BACKGROUND: The changes induced in host immunity and the tumor microenvironment by chemotherapy have been shown to impact immunotherapy response in both a positive and a negative fashion. Temozolomide is the most common chemotherapy used to treat glioblastoma (GBM) and has been shown to have variabl...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Karachi, Aida, Yang, Changlin, Dastmalchi, Farhad, Sayour, Elias J, Huang, Jianping, Azari, Hassan, Long, Yu, Flores, Catherine, Mitchell, Duane A, Rahman, Maryam
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6556847/
https://ncbi.nlm.nih.gov/pubmed/30668768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz015
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