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The histone demethylase JMJD2B is critical for p53-mediated autophagy and survival in Nutlin-treated cancer cells
Autophagy promotes cancer cell survival in response to p53 activation by the anticancer agent Nutlin-3a (Nutlin). We reported previously that Nutlin kills MDM2-amplified cancer cells and that this killing is associated with an inhibition of glucose metabolism, reduced α-ketoglutarate (α-KG) levels,...
Shranjeno v:
| izdano v: | J Biol Chem |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Biochemistry and Molecular Biology
2019
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6556578/ https://ncbi.nlm.nih.gov/pubmed/31036564 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.007122 |
| Oznake: |
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