Inhibition of phosphodiesterase‐4 attenuates murine ulcerative colitis through interference with mucosal immunity

BACKGROUND AND PURPOSE: Ulcerative colitis (UC) is an aetiologically refractory inflammatory disease, accompanied by dysfunction of the epithelial barrier and intestinal inflammation. Phosphodiesterase‐4 (PDE4) serves as an intracellular proinflammatory enzyme, hydrolyzing and inactivating cAMP. Tho...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Br J Pharmacol
Main Authors: Li, Heng, Fan, Chen, Feng, Chunlan, Wu, Yanwei, Lu, Huimin, He, Peilan, Yang, Xiaoqian, Zhu, Fenghua, Qi, Qing, Gao, Yuanzhuo, Zuo, Jianping, Tang, Wei
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2019
Teme:
Research Papers
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6555859/
https://ncbi.nlm.nih.gov/pubmed/30883697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14667
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