Inhibition of phosphodiesterase‐4 attenuates murine ulcerative colitis through interference with mucosal immunity

BACKGROUND AND PURPOSE: Ulcerative colitis (UC) is an aetiologically refractory inflammatory disease, accompanied by dysfunction of the epithelial barrier and intestinal inflammation. Phosphodiesterase‐4 (PDE4) serves as an intracellular proinflammatory enzyme, hydrolyzing and inactivating cAMP. Tho...

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Bibliografiska uppgifter
I publikationen:Br J Pharmacol
Huvudupphovsmän: Li, Heng, Fan, Chen, Feng, Chunlan, Wu, Yanwei, Lu, Huimin, He, Peilan, Yang, Xiaoqian, Zhu, Fenghua, Qi, Qing, Gao, Yuanzhuo, Zuo, Jianping, Tang, Wei
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2019
Ämnen:
Research Papers
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6555859/
https://ncbi.nlm.nih.gov/pubmed/30883697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14667
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