Inhibition of phosphodiesterase‐4 attenuates murine ulcerative colitis through interference with mucosal immunity

BACKGROUND AND PURPOSE: Ulcerative colitis (UC) is an aetiologically refractory inflammatory disease, accompanied by dysfunction of the epithelial barrier and intestinal inflammation. Phosphodiesterase‐4 (PDE4) serves as an intracellular proinflammatory enzyme, hydrolyzing and inactivating cAMP. Tho...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Li, Heng, Fan, Chen, Feng, Chunlan, Wu, Yanwei, Lu, Huimin, He, Peilan, Yang, Xiaoqian, Zhu, Fenghua, Qi, Qing, Gao, Yuanzhuo, Zuo, Jianping, Tang, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6555859/
https://ncbi.nlm.nih.gov/pubmed/30883697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14667
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