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Enantioselective synthesis of cis-hydrobenzofurans bearing all-carbon quaternary stereocenters and application to total synthesis of (‒)-morphine

(‒)-Morphine, which is selected as an essential medicine by World Health Organization, is widely applied in the treatment of the pain-related diseases. Due to its synthetically challenging molecular architecture and important clinical role, extensive synthetic studies of morphine-type alkaloids have...

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Foilsithe in:Nat Commun
Main Authors: Zhang, Qing, Zhang, Fu-Min, Zhang, Chang-Sheng, Liu, Si-Zhan, Tian, Jin-Miao, Wang, Shao-Hua, Zhang, Xiao-Ming, Tu, Yong-Qiang
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2019
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6555830/
https://ncbi.nlm.nih.gov/pubmed/31175289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10398-4
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