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Facile Preparation of Spirolactones by an Alkoxycarbonyl Radical Cyclization Cross-Coupling Cascade

An alkoxycarbonyl radical cyclization cross-coupling cascade has been developed that allows functionalized γ-butyrolactones to be prepared in one step from simple tertiary alcohol-derived homoallylic oxalate precursors. The reaction succeeds with aryl and vinyl electrophiles and is compatible with h...

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Publicado en:Angew Chem Int Ed Engl
Autores principales: Weires, Nicholas A., Slutskyy, Yuriy, Overman, Larry E.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6555670/
https://ncbi.nlm.nih.gov/pubmed/30989757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201903353
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