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Consequences of Performing Parallel Dose Finding Trials in Heterogeneous Groups of Patients
Patient heterogeneity, in which patients can be grouped by risk of toxicity, is a design challenge in early phase dose finding trials. Carrying out independent trials for each group is a readily available approach for dose finding. However, this often leads to dose recommendations that violate the k...
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| Udgivet i: | JNCI Cancer Spectr |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6555302/ https://ncbi.nlm.nih.gov/pubmed/31206097 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jncics/pkz013 |
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