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OR05-2 Targeted Inhibition of Glutamate Dehydrogenase by Alpha-Tocopherol: A Potential Novel Treatment for Hyperinsulinism Hyperammonemia Syndrome

Congenital hyperinsulinism is a rare genetic disorder that causes severe hypoglycemia and can lead to permanent brain damage if inadequately controlled. Gain of function mutations in glutamate dehydrogenase (GDH) result in hyperinsulinism hyperammonemia (HI/HA) syndrome, the second most common cause...

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Detalhes bibliográficos
Publicado no:J Endocr Soc
Main Authors: Rosenfeld, Elizabeth, Li, Changhong, De Leon-Crutchlow, Diva
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6555078/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/js.2019-OR05-2
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