OR24-5 Aberrant DNA Methylation in Regulatory Genomic Elements Are Associated with Invasive Behavior of Pituitary Macroadenomas: An Integrative Analysis of Epigenome-Wide Studies

A significant proportion of pituitary tumors (PT) invade adjacent structures. Few putative somatic mutations or copy number alterations have been associated with PT invasiveness. DNA methylation abnormalities in regulatory regions are known to impact gene expression and cancer behavior, but have not...

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Detalhes bibliográficos
Publicado no:J Endocr Soc
Main Authors: Mosella, Maritza, Sabedot, Thais, Malta, Tathiane, Felicella, Michelle, Aho, Todd, Poisson, Laila, deCarvalho, Ana, Noushmehr, Houtan, Rock, Jack, Castro, Ana Valeria
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2019
Assuntos:
Neuroendocrinology and Pituitary
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6554889/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/js.2019-OR24-5
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