Vulnerability of invasive glioblastoma cells to lysosomal membrane destabilization

The current clinical care of glioblastomas leaves behind invasive, radio‐ and chemo‐resistant cells. We recently identified mammary‐derived growth inhibitor (MDGI/FABP3) as a biomarker for invasive gliomas. Here, we demonstrate a novel function for MDGI in the maintenance of lysosomal membrane integ...

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Bibliographic Details
Published in:EMBO Mol Med
Main Authors: Le Joncour, Vadim, Filppu, Pauliina, Hyvönen, Maija, Holopainen, Minna, Turunen, S Pauliina, Sihto, Harri, Burghardt, Isabel, Joensuu, Heikki, Tynninen, Olli, Jääskeläinen, Juha, Weller, Michael, Lehti, Kaisa, Käkelä, Reijo, Laakkonen, Pirjo
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2019
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6554674/
https://ncbi.nlm.nih.gov/pubmed/31068339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201809034
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