Mutating chikungunya virus non‐structural protein produces potent live‐attenuated vaccine candidate

Currently, there are no commercially available live‐attenuated vaccines against chikungunya virus (CHIKV). Here, CHIKVs with mutations in non‐structural proteins (nsPs) were investigated for their suitability as attenuated CHIKV vaccines. R532H mutation in nsP1 caused reduced infectivity in mouse ta...

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Detalhes bibliográficos
Publicado no:EMBO Mol Med
Main Authors: Chan, Yi‐Hao, Teo, Teck‐Hui, Utt, Age, Tan, Jeslin JL, Amrun, Siti Naqiah, Abu Bakar, Farhana, Yee, Wearn‐Xin, Becht, Etienne, Lee, Cheryl Yi‐Pin, Lee, Bernett, Rajarethinam, Ravisankar, Newell, Evan, Merits, Andres, Carissimo, Guillaume, Lum, Fok‐Moon, Ng, Lisa FP
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6554673/
https://ncbi.nlm.nih.gov/pubmed/31015278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201810092
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