Mutating chikungunya virus non‐structural protein produces potent live‐attenuated vaccine candidate

Abstract Currently, there are no commercially available live‐attenuated vaccines against chikungunya virus (CHIKV). Here, CHIKVs with mutations in non‐structural proteins (nsPs) were investigated for their suitability as attenuated CHIKV vaccines. R532H mutation in nsP1 caused reduced infectivity in...

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Autori principali:	Yi‐Hao Chan, Teck‐Hui Teo, Age Utt, Jeslin JL Tan, Siti Naqiah Amrun, Farhana Abu Bakar, Wearn‐Xin Yee, Etienne Becht, Cheryl Yi‐Pin Lee, Bernett Lee, Ravisankar Rajarethinam, Evan Newell, Andres Merits, Guillaume Carissimo, Fok‐Moon Lum, Lisa FP Ng
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Springer Nature 2019-04-01
Serie:	EMBO Molecular Medicine
Soggetti:	chikungunya live‐attenuated vaccine mutation neutralizing antibody non‐structural protein
Accesso online:	https://doi.org/10.15252/emmm.201810092
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