Potentiating Oncolytic Virus-Induced Immune-Mediated Tumor Cell Killing Using Histone Deacetylase Inhibition

A clinical oncolytic herpes simplex virus (HSV) encoding granulocyte-macrophage colony-stimulating factor (GM-CSF), talimogene laherparepvec, causes regression of injected and non-injected melanoma lesions in patients and is now licensed for clinical use in advanced melanoma. To date, limited data a...

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Publicat a:Mol Ther
Autors principals: Jennings, Victoria A., Scott, Gina B., Rose, Ailsa M.S., Scott, Karen J., Migneco, Gemma, Keller, Brian, Reilly, Katrina, Donnelly, Oliver, Peach, Howard, Dewar, Donald, Harrington, Kevin J., Pandha, Hardev, Samson, Adel, Vile, Richard G., Melcher, Alan A., Errington-Mais, Fiona
Format: Artigo
Idioma:Inglês
Publicat: American Society of Gene & Cell Therapy 2019
Matèries:
Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6554638/
https://ncbi.nlm.nih.gov/pubmed/31053413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2019.04.008
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