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Role of Metformin and AKT Axis Modulation in the Reversion of Hypoxia Induced TMZ-Resistance in Glioma Cells

Hypoxia is a key driver of tumor adaptation promoting tumor progression and resistance to therapy. Hypoxia related pathways might represent attractive targets for the treatment of Glioblastoma Multiforme (GBM), that up to date is characterized by a poor prognosis. Primary aim of this study was to in...

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Foilsithe in:Front Oncol
Main Authors: Lo Dico, Alessia, Valtorta, Silvia, Ottobrini, Luisa, Moresco, Rosa Maria
Formáid: Artigo
Teanga:Inglês
Foilsithe: Frontiers Media S.A. 2019
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6554426/
https://ncbi.nlm.nih.gov/pubmed/31214505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.00463
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