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Factors other than hTau overexpression that contribute to tauopathy-like phenotype in rTg4510 mice

The tauopathy-like phenotype observed in the rTg4510 mouse line, in which human tau(P301L) expression specifically within the forebrain can be temporally controlled, has largely been attributed to high overexpression of mutant human tau in the forebrain region. Unexpectedly, we found that in a diffe...

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Bibliografski detalji
Izdano u:Nat Commun
Glavni autori: Gamache, Julia, Benzow, Kellie, Forster, Colleen, Kemper, Lisa, Hlynialuk, Chris, Furrow, Eva, Ashe, Karen H., Koob, Michael D.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6554306/
https://ncbi.nlm.nih.gov/pubmed/31171783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10428-1
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