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LRP1 Deficiency in Vascular SMC Leads To Pulmonary Arterial Hypertension That Is Reversed By PPARγ Activation
RATIONALE: Arterial remodeling, a hallmark of many cardiovascular pathologies including pulmonary arterial hypertension (PAH), is regulated by TGFβ1-TGFβ receptors and the antagonistic, vasoprotective BMPR2-PPARγ axis. However, it is unclear which factors drive detrimental TGFβ1 pathways in the hype...
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| Publicado en: | Circ Res |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6554044/ https://ncbi.nlm.nih.gov/pubmed/31023188 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.119.315088 |
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