PPARγ COUNTERACTS LRP1-INDUCED VASCULAR CALCIFICATION BY INHIBITING A WNT5A SIGNALING PATHWAY

Vascular calcification is a hallmark of advanced atherosclerosis, but the underlying mechanisms remain unknown. Here we show that deletion of the nuclear receptor PPARγ in vascular smooth muscle cells (vSMCs) of Low Density Lipoprotein receptor (LDLr) deficient mice fed an atherogenic high-cholester...

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Main Authors: Woldt, Estelle, Terrand, Jérome, Mlih, Mohamed, Matz, Rachel L., Bruban, Véronique, Coudane, Fanny, Foppolo, Sophie, El Asmar, Zeina, Chollet, Maria Eugenia, Ninio, Ewa, Bednarczyk, Audrey, Thiersé, Danièle, Schaeffer, Christine, Van Dorsselaer, Alain, Boudier, Christian, Wahli, Walter, Chambon, Pierre, Metzger, Daniel, Herz, Joachim, Boucher, Philippe
Format: Artigo
Language:Inglês
Published: 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3523725/
https://ncbi.nlm.nih.gov/pubmed/23011131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2087
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