LRP1 Controls Intracellular Cholesterol Storage and Fatty Acid Synthesis through Modulation of Wnt Signaling

The low-density lipoprotein receptor-related protein LRP1 is a cell surface receptor with functions in diverse physiological pathways, including lipid metabolism. Here we show that LRP1-deficient fibroblasts accumulate high levels of intracellular cholesterol and cholesteryl-ester when stimulated fo...

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Detalhes bibliográficos
Main Authors: Terrand, Jérome, Bruban, Véronique, Zhou, Li, Gong, Wanfeng, El Asmar, Zeina, May, Petra, Zurhove, Kai, Haffner, Philipp, Philippe, Claude, Woldt, Estelle, Matz, Rachel L., Gracia, Céline, Metzger, Daniel, Auwerx, Johan, Herz, Joachim, Boucher, Philippe
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2610522/
https://ncbi.nlm.nih.gov/pubmed/18990694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806538200
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