Loss of the adaptor protein ShcA in endothelial cells protects against monocyte macrophage adhesion, LDL-oxydation, and atherosclerotic lesion formation

ShcA is an adaptor protein that binds to the cytoplasmic tail of receptor tyrosine kinases and of the Low Density Lipoprotein-related receptor 1 (LRP1), a trans-membrane receptor that protects against atherosclerosis. Here, we examined the role of endothelial ShcA in atherosclerotic lesion formation...

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Gepubliceerd in:Sci Rep
Hoofdauteurs: Abou-Jaoude, Antoine, Badiqué, Lise, Mlih, Mohamed, Awan, Sara, Guo, Sunning, Lemle, Alexandre, Abboud, Clauda, Foppolo, Sophie, Host, Lionel, Terrand, Jérôme, Justiniano, Hélène, Herz, Joachim, Matz, Rachel L., Boucher, Philippe
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5852050/
https://ncbi.nlm.nih.gov/pubmed/29540796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-22819-3
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