Substrate binding allosterically relieves autoinhibition of the pseudokinase TRIB1

The Tribbles family of pseudokinases recruits substrates to the ubiquitin ligase COP1 to facilitate ubiquitylation. CCAAT/enhancer-binding protein (C/EBP) family transcription factors are crucial Tribbles substrates in adipocyte and myeloid cell development. We found that the TRIB1 pseudokinase was...

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Publicado en:Sci Signal
Main Authors: Jamieson, Sam A., Ruan, Zheng, Burgess, Abigail E., Curry, Jack R., McMillan, Hamish D., Brewster, Jodi L., Dunbier, Anita K., Axtman, Alison D., Kannan, Natarajan, Mace, Peter D.
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6553639/
https://ncbi.nlm.nih.gov/pubmed/30254053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aau0597
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