Colchicine Binding Site Agent DJ95 Overcomes Drug Resistance and Exhibits Antitumor Efficacy

Interfering with microtubule dynamics is a well-established strategy in cancer treatment; however, many microtubule-targeting agents are associated with drug resistance and adverse effects. Substantial evidence points to ATP-binding cassette (ABC) transporters as critical players in the development...

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Detalhes bibliográficos
Publicado no:Mol Pharmacol
Main Authors: Arnst, Kinsie E., Wang, Yuxi, Lei, Zi-Ning, Hwang, Dong-Jin, Kumar, Gyanendra, Ma, Dejian, Parke, Deanna N., Chen, Qiang, Yang, Jinliang, White, Stephen W., Seagroves, Tiffany N., Chen, Zhe-Sheng, Miller, Duane D., Li, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2019
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6553560/
https://ncbi.nlm.nih.gov/pubmed/31043459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.118.114801
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