An unusual Burkholderia gladioli double chain-initiating nonribosomal peptide synthetase assembles ‘fungal’ icosalide antibiotics

Burkholderia is a multi-talented genus of Gram-negative bacteria, which in recent years has become increasingly recognised as a promising source of bioactive natural products. Metabolite profiling of Burkholderia gladioli BCC0238 showed that it produces the asymmetric lipopeptidiolide antibiotic ico...

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Veröffentlicht in:Chem Sci
Hauptverfasser: Jenner, Matthew, Jian, Xinyun, Dashti, Yousef, Masschelein, Joleen, Hobson, Christian, Roberts, Douglas M., Jones, Cerith, Harris, Simon, Parkhill, Julian, Raja, Huzefa A., Oberlies, Nicholas H., Pearce, Cedric J., Mahenthiralingam, Eshwar, Challis, Gregory L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Royal Society of Chemistry 2019
Schlagworte:
Chemistry
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6553374/
https://ncbi.nlm.nih.gov/pubmed/31293732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8sc04897e
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