SUN-532 Interferon Gamma-1b Does Not Increase Markers of Bone Resorption in Autosomal Dominant Osteopetrosis

In autosomal dominant osteopetrosis type 2 (ADO2) CLCN7 mutations cause impaired osteoclast function. Severe consequences include skeletal fragility despite high bone mass, osteomyelitis, osteonecrosis, bone marrow failure, and severe cranial nerve impingement. There is no effective medical treatmen...

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Bibliographic Details
Published in:J Endocr Soc
Main Authors: Imel, Erik, Liu, Ziyue, Acton, Dena, Coffman, Melissa, Gebregziabher, Netsanet, Tong, Yan, Econs, Michael
Format: Artigo
Language:Inglês
Published: Endocrine Society 2019
Subjects:
Bone and Mineral Metabolism
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6552866/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/js.2019-SUN-532
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