SUN-024 Uncovering a Novel Role for Nuclear Receptor Fxr and Shp in Regulating N-Linked Glycosylation

Nuclear receptor Farnesoid X Receptor (Fxr) and Small Heterodimer Partner (Shp) are key regulators of glucose, fat and bile acid homeostasis. As expected, liver-specific deletion of both Fxr and Shp (LDKO) sensitizes mice to bile acid excess. Surprisingly, high throughput RNA-sequencing analysis rev...

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Vydáno v:J Endocr Soc
Hlavní autoři: Mathur, Bhoomika, Anakk, Sayeepriyadarshini
Médium: Artigo
Jazyk:Inglês
Vydáno: Endocrine Society 2019
Témata:
Steroid Hormones and Receptors
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6552847/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/js.2019-SUN-024
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