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Phosphorylation of HSP90 by protein kinase A is essential for the nuclear translocation of androgen receptor

The androgen receptor (AR) is often activated in prostate cancer patients undergoing androgen-ablative therapy because of the activation of cellular pathways that stimulate the AR despite low androgen levels. In many of these tumors, the cAMP-dependent protein kinase A (PKA) pathway is activated. Pr...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Dagar, Manisha, Singh, Julie Pratibha, Dagar, Gunjan, Tyagi, Rakesh K., Bagchi, Gargi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6552429/
https://ncbi.nlm.nih.gov/pubmed/30992362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.007420
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