Selective cleavage of fibrinogen by diverse proteinases initiates innate allergic and antifungal immunity through CD11b

Proteinases are essential drivers of allergic airway disease and innate antifungal immunity in part through their ability cleave the clotting factor fibrinogen (FBG) into fibrinogen cleavage products (FCPs) that signal through Toll-like receptor 4 (TLR4). However, the mechanism by which FCPs engage...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Landers, Cameron T., Tung, Hui-Ying, Knight, J. Morgan, Madison, Matthew C., Wu, Yifan, Zeng, Zhimin, Porter, Paul C., Rodriguez, Antony, Flick, Matthew J., Kheradmand, Farrah, Corry, David B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6552423/
https://ncbi.nlm.nih.gov/pubmed/30992366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006724
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