Selective cleavage of fibrinogen by diverse proteinases initiates innate allergic and antifungal immunity through CD11b

Proteinases are essential drivers of allergic airway disease and innate antifungal immunity in part through their ability cleave the clotting factor fibrinogen (FBG) into fibrinogen cleavage products (FCPs) that signal through Toll-like receptor 4 (TLR4). However, the mechanism by which FCPs engage...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Landers, Cameron T., Tung, Hui-Ying, Knight, J. Morgan, Madison, Matthew C., Wu, Yifan, Zeng, Zhimin, Porter, Paul C., Rodriguez, Antony, Flick, Matthew J., Kheradmand, Farrah, Corry, David B.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2019
Materias:
Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6552423/
https://ncbi.nlm.nih.gov/pubmed/30992366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006724
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