Cartilage Penetrating Cationic Peptide Carriers for Applications in Drug Delivery to Avascular Negatively Charged Tissues

Drug delivery to avascular, negatively charged tissues like cartilage remains a challenge. The constant turnover of synovial fluid results in short residence time of administered drugs in the joint space and the dense negatively charged matrix of cartilage hinders their diffusive transport. Drugs ar...

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Udgivet i:Acta Biomater
Main Authors: Vedadghavami, Armin, Wagner, Erica K., Mehta, Shikhar, He, Tengfei, Zhang, Chenzhen, Bajpayee, Ambika G.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6551323/
https://ncbi.nlm.nih.gov/pubmed/30529083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.actbio.2018.12.004
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