Increased serine synthesis provides an advantage for tumors arising in tissues where serine levels are limiting

Tumors exhibit altered metabolism compared to normal tissues. Many cancers upregulate expression of serine synthesis pathway enzymes, and some tumors exhibit copy number gain of the gene encoding the first enzyme in the pathway, phosphoglycerate dehydrogenase (PHGDH). However, whether increased seri...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cell Metab
Main Authors: Sullivan, Mark R., Mattaini, Katherine R., Dennstedt, Emily A., Nguyen, Anna A., Reilly, Montana F., Meeth, Katrina, Muir, Alexander, Darnell, Alicia M., Bosenberg, Marcus W., Lewis, Caroline A., Vander Heiden, Matthew G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6551255/
https://ncbi.nlm.nih.gov/pubmed/30905671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2019.02.015
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados