Increased serine synthesis provides an advantage for tumors arising in tissues where serine levels are limiting

Tumors exhibit altered metabolism compared to normal tissues. Many cancers upregulate expression of serine synthesis pathway enzymes, and some tumors exhibit copy number gain of the gene encoding the first enzyme in the pathway, phosphoglycerate dehydrogenase (PHGDH). However, whether increased seri...

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Publicat a:Cell Metab
Autors principals: Sullivan, Mark R., Mattaini, Katherine R., Dennstedt, Emily A., Nguyen, Anna A., Reilly, Montana F., Meeth, Katrina, Muir, Alexander, Darnell, Alicia M., Bosenberg, Marcus W., Lewis, Caroline A., Vander Heiden, Matthew G.
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6551255/
https://ncbi.nlm.nih.gov/pubmed/30905671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2019.02.015
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