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MON-459 ONO-5788, a Novel Oral Small Molecule Somatostatin Receptor Type-2 (SST2) Agonist, Attenuates GH Hypersecretion in Human GH-Secreting, Pituitary Adenoma-Derived Cells

Somatostatin receptor ligands (SRL) and GHR antagonists are used for persistent or recurrent acromegaly following noncurative surgery and as primary therapy for patients unsuitable for surgery. We tested in vitro action of a novel oral SRL compound ONO-5788 and its active metabolite (ONO-ST1-641) wh...

詳細記述

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書誌詳細
出版年:J Endocr Soc
主要な著者: Zhou, Cuiqi, Bonert, Vivien, Mamelak, Adam, Kelly, Daniel, Barkhoudarian, Garni, Hoon, Dave, Komagata, Tatsuya, Shinozaki, Koji, Melmed, Shlomo
フォーマット: Artigo
言語:Inglês
出版事項: Endocrine Society 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6551177/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/js.2019-MON-459
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