MON-459 ONO-5788, a Novel Oral Small Molecule Somatostatin Receptor Type-2 (SST2) Agonist, Attenuates GH Hypersecretion in Human GH-Secreting, Pituitary Adenoma-Derived Cells

Somatostatin receptor ligands (SRL) and GHR antagonists are used for persistent or recurrent acromegaly following noncurative surgery and as primary therapy for patients unsuitable for surgery. We tested in vitro action of a novel oral SRL compound ONO-5788 and its active metabolite (ONO-ST1-641) wh...

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Detalhes bibliográficos
Publicado no:J Endocr Soc
Main Authors: Zhou, Cuiqi, Bonert, Vivien, Mamelak, Adam, Kelly, Daniel, Barkhoudarian, Garni, Hoon, Dave, Komagata, Tatsuya, Shinozaki, Koji, Melmed, Shlomo
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2019
Assuntos:
Neuroendocrinology and Pituitary
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6551177/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/js.2019-MON-459
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