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MON-493 A Unique Case of Severe Osteogenesis Imperfecta Due to a Novel Heterozygous Mutation in COL1A1 Gene with Overlapping Hypophosphatasia Phenotype

Background: Osteogenesis imperfecta (OI) is a rare heterogeneous bone fragility disease due to collagen defect most often caused by autosomal dominant (AD) COL1A1 or COL1A2 gene mutations. Severe forms of Hypophosphatasia (HPP) may phenotypically resemble OI, is a distinct disorder of hypomineraliza...

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Detalhes bibliográficos
Publicado no:J Endocr Soc
Main Authors: Bakhach, Marwan, Ryabets-Lienhard, Anna, Pitukcheewanont, Pisit
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6550687/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/js.2019-MON-493
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