Inhibition of CaMKK2 Enhances Fracture Healing by Stimulating Indian Hedgehog Signaling and Accelerating Endochondral Ossification

Approximately ten percent of all bone fractures do not heal, resulting in patient morbidity and healthcare costs. However, no pharmacological treatments are currently available to promote efficient bone healing. Inhibition of Ca(2+)/calmodulin (CaM)-dependent protein kinase kinase 2 (CaMKK2) reverse...

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Publié dans:J Bone Miner Res
Auteurs principaux: Williams, Justin N., Kambrath, Anuradha Valiya, Patel, Roshni B., Kang, Kyung Shin, Mével, Elsa, Li, Yong, Cheng, Ying-Hua, Pucylowski, Austin J, Hassert, Mariah A., Voor, Michael J., Kacena, Melissa A., Thompson, William R., Warden, Stuart J., Burr, David B., Allen, Matthew R., Robling, Alexander G, Sankar, Uma
Format: Artigo
Langue:Inglês
Publié: 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6549722/
https://ncbi.nlm.nih.gov/pubmed/29314250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.3379
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