Inhibition of CaMKK2 Enhances Fracture Healing by Stimulating Indian Hedgehog Signaling and Accelerating Endochondral Ossification

Approximately ten percent of all bone fractures do not heal, resulting in patient morbidity and healthcare costs. However, no pharmacological treatments are currently available to promote efficient bone healing. Inhibition of Ca(2+)/calmodulin (CaM)-dependent protein kinase kinase 2 (CaMKK2) reverse...

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Bibliografiska uppgifter
I publikationen:J Bone Miner Res
Huvudupphovsmän: Williams, Justin N., Kambrath, Anuradha Valiya, Patel, Roshni B., Kang, Kyung Shin, Mével, Elsa, Li, Yong, Cheng, Ying-Hua, Pucylowski, Austin J, Hassert, Mariah A., Voor, Michael J., Kacena, Melissa A., Thompson, William R., Warden, Stuart J., Burr, David B., Allen, Matthew R., Robling, Alexander G, Sankar, Uma
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2018
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6549722/
https://ncbi.nlm.nih.gov/pubmed/29314250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.3379
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