Inhibition of CaMKK2 Enhances Fracture Healing by Stimulating Indian Hedgehog Signaling and Accelerating Endochondral Ossification

Approximately ten percent of all bone fractures do not heal, resulting in patient morbidity and healthcare costs. However, no pharmacological treatments are currently available to promote efficient bone healing. Inhibition of Ca(2+)/calmodulin (CaM)-dependent protein kinase kinase 2 (CaMKK2) reverse...

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Udgivet i:J Bone Miner Res
Main Authors: Williams, Justin N., Kambrath, Anuradha Valiya, Patel, Roshni B., Kang, Kyung Shin, Mével, Elsa, Li, Yong, Cheng, Ying-Hua, Pucylowski, Austin J, Hassert, Mariah A., Voor, Michael J., Kacena, Melissa A., Thompson, William R., Warden, Stuart J., Burr, David B., Allen, Matthew R., Robling, Alexander G, Sankar, Uma
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6549722/
https://ncbi.nlm.nih.gov/pubmed/29314250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.3379
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