Combination of insulin with a GLP1 agonist is associated with better memory and normal expression of insulin receptor pathway genes in a mouse model of Alzheimer’s disease.

Disruption of brain insulin signaling may explain the higher Alzheimer’s disease (AD) risk among type 2 diabetic (T2D) patients. There is evidence from in vitro and human postmortem studies that combination of insulin with hypoglycemic medications is neuroprotective and associated with less amyloid...

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Veröffentlicht in:J Mol Neurosci
Hauptverfasser: Robinson, Ari, Lubitz, Irit, Atrakchi-Baranes, Dana, Licht-Murava, Avital, Katsel, Pavel, Leroith, Derek, Liraz-Zaltsman, Sigal, Haroutunian, Vahram, Beeri, Michal Schnaider
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6549496/
https://ncbi.nlm.nih.gov/pubmed/30635783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12031-019-1257-9
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