Uncoupling the Senescence-Associated Secretory Phenotype from Cell Cycle Exit via Interleukin-1 Inactivation Unveils Its Protumorigenic Role

Cellular senescence has emerged as a potent tumor suppressor mechanism in numerous human neoplasias. Senescent cells secrete a distinct set of factors, collectively termed the senescence-associated secretory phenotype (SASP), which has been postulated to carry both pro- and antitumorigenic propertie...

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Veröffentlicht in:Mol Cell Biol
Hauptverfasser: Lau, Lena, Porciuncula, Angelo, Yu, Alex, Iwakura, Yoichiro, David, Gregory
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2019
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6549465/
https://ncbi.nlm.nih.gov/pubmed/30988157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00586-18
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