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Unexpected Role of Matrix Gla Protein in Osteoclasts: Inhibiting Osteoclast Differentiation and Bone Resorption
Matrix Gla protein (MGP) is an extracellular protein responsible for inhibiting mineralization. MGP inhibits osteoblast mineralization and bone formation by regulating the deposition of bone matrix. However, Mgp(–/–) mice display an osteopenic phenotype. To explain this contradiction, we investigate...
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| Vydáno v: | Mol Cell Biol |
|---|---|
| Hlavní autoři: | , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society for Microbiology
2019
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6549463/ https://ncbi.nlm.nih.gov/pubmed/30988158 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00012-19 |
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