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Unexpected Role of Matrix Gla Protein in Osteoclasts: Inhibiting Osteoclast Differentiation and Bone Resorption
Matrix Gla protein (MGP) is an extracellular protein responsible for inhibiting mineralization. MGP inhibits osteoblast mineralization and bone formation by regulating the deposition of bone matrix. However, Mgp(–/–) mice display an osteopenic phenotype. To explain this contradiction, we investigate...
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| 出版年: | Mol Cell Biol |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Microbiology
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6549463/ https://ncbi.nlm.nih.gov/pubmed/30988158 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00012-19 |
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