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Unexpected Role of Matrix Gla Protein in Osteoclasts: Inhibiting Osteoclast Differentiation and Bone Resorption
Matrix Gla protein (MGP) is an extracellular protein responsible for inhibiting mineralization. MGP inhibits osteoblast mineralization and bone formation by regulating the deposition of bone matrix. However, Mgp(–/–) mice display an osteopenic phenotype. To explain this contradiction, we investigate...
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| Publicado no: | Mol Cell Biol |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6549463/ https://ncbi.nlm.nih.gov/pubmed/30988158 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00012-19 |
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