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Glycan-independent Gamete Recognition Triggers Egg Zinc Sparks and ZP2 Cleavage to Prevent Polyspermy
The zona pellucida surrounding ovulated eggs regulates monospermic fertilization necessary for successful development. Using mouse transgenesis, we document that the N-terminus of ZP2 is sufficient for sperm binding to the zona matrix and for in vivo fertility. Sperm binding is independent of ZP2 gl...
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| Published in: | Dev Cell |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2018
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6549238/ https://ncbi.nlm.nih.gov/pubmed/30122633 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2018.07.020 |
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