Protein kinase A inhibits tumor mutator APOBEC3B through phosphorylation

APOBEC3B cytidine deaminase (A3B) catalyzes cytosine into uracil in single-strand DNA and induces C-to-T mutations in genomic DNA of various types of tumors. Accumulation of APOBEC signature mutations is correlated with a worse prognosis for patients with breast cancer or multiple myeloma, suggestin...

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Pubblicato in:Sci Rep
Autori principali: Matsumoto, Tadahiko, Shirakawa, Kotaro, Yokoyama, Masaru, Fukuda, Hirofumi, Sarca, Anamaria Daniela, Koyabu, Sukenao, Yamazaki, Hiroyuki, Kazuma, Yasuhiro, Matsui, Hiroyuki, Maruyama, Wataru, Nagata, Kayoko, Tanabe, Fumiko, Kobayashi, Masayuki, Shindo, Keisuke, Morishita, Ryo, Sato, Hironori, Takaori-Kondo, Akifumi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6549188/
https://ncbi.nlm.nih.gov/pubmed/31165764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-44407-9
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