Endogenous APOBEC3B Overexpression Constitutively Generates DNA Substitutions and Deletions in Myeloma Cells

Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like (APOBEC) DNA cytosine deaminases have emerged as potential genomic mutators in various cancers. Multiple myeloma accumulates APOBEC signature mutations as it progresses; however, the mechanisms underlying APOBEC signature acquisition an...

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Publicado no:Sci Rep
Main Authors: Yamazaki, Hiroyuki, Shirakawa, Kotaro, Matsumoto, Tadahiko, Hirabayashi, Shigeki, Murakawa, Yasuhiro, Kobayashi, Masayuki, Sarca, Anamaria Daniela, Kazuma, Yasuhiro, Matsui, Hiroyuki, Maruyama, Wataru, Fukuda, Hirofumi, Shirakawa, Ryutaro, Shindo, Keisuke, Ri, Masaki, Iida, Shinsuke, Takaori-Kondo, Akifumi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6509214/
https://ncbi.nlm.nih.gov/pubmed/31073151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-43575-y
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