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Disordered RNA chaperones can enhance nucleic acid folding via local charge screening

RNA chaperones are proteins that aid in the folding of nucleic acids, but remarkably, many of these proteins are intrinsically disordered. How can these proteins function without a well-defined three-dimensional structure? Here, we address this question by studying the hepatitis C virus core protein...

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Podrobná bibliografie
Vydáno v:Nat Commun
Hlavní autoři: Holmstrom, Erik D., Liu, Zhaowei, Nettels, Daniel, Best, Robert B., Schuler, Benjamin
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6549165/
https://ncbi.nlm.nih.gov/pubmed/31165735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10356-0
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