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Disordered RNA chaperones can enhance nucleic acid folding via local charge screening

RNA chaperones are proteins that aid in the folding of nucleic acids, but remarkably, many of these proteins are intrinsically disordered. How can these proteins function without a well-defined three-dimensional structure? Here, we address this question by studying the hepatitis C virus core protein...

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Pubblicato in:Nat Commun
Autori principali: Holmstrom, Erik D., Liu, Zhaowei, Nettels, Daniel, Best, Robert B., Schuler, Benjamin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6549165/
https://ncbi.nlm.nih.gov/pubmed/31165735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10356-0
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