Novel neurosteroid hypnotic blocks T-type calcium channel-dependent rebound burst firing and suppresses long-term potentiation in the rat subiculum

BACKGROUND: Hypnotics and general anaesthetics impair memory by altering hippocampal synaptic plasticity. We recently reported on a neurosteroid analogue with potent hypnotic activity [(3β,5β,17β)-3-hydroxyandrostane-17-carbonitrile; 3β-OH], which does not cause developmental neurotoxicity in rat pu...

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Detalles Bibliográficos
Publicado en:Br J Anaesth
Autores principales: Joksimovic, Srdjan M., Izumi, Yukitoshi, Joksimovic, Sonja Lj., Tesic, Vesna, Krishnan, Kathiresan, Asnake, Betelehem, Jevtovic-Todorovic, Vesna, Covey, Douglas F., Zorumski, Charles F., Todorovic, Slobodan M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2019
Materias:
Neuroscience and Neuroanaesthesia
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6549045/
https://ncbi.nlm.nih.gov/pubmed/30916017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bja.2019.01.029
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