HDAC8 regulates a stress response pathway in melanoma to mediate escape from BRAF inhibitor therapy

Melanoma cells have the ability to switch to a dedifferentiated, invasive phenotype in response to multiple stimuli. Here we show that exposure of melanomas to multiple stresses including BRAF-MEK inhibitor therapy, hypoxia, and UV irradiation leads to an increase in histone deacetylase 8 (HDAC8) ac...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Emmons, Michael F., Faião-Flores, Fernanda, Sharma, Ritin, Thapa, Ram, Messina, Jane L., Becker, Jurgen C., Schadendorf, Dirk, Seto, Edward, Sondak, Vernon K., Koomen, John M., Chen, Yian A., Lau, Eric K., Wan, Lixin, Licht, Jonathan D., Smalley, Keiran S.M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6548652/
https://ncbi.nlm.nih.gov/pubmed/30987999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-0040
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados