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Programmed cell death ligand-1 (PD-L1) and CD8 expression profiling identify an immunologic subtype of pancreatic ductal adenocarcinomas with favorable survival

Immune checkpoint therapy has failed to demonstrate meaningful clinical benefit in unselected cases of pancreatic adenocarcinoma (PDAC), but a subset of PDACs are known to upregulate pathways involved in acquired immune suppression. Further delineation of immunologic subtypes of PDAC is necessary to...

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Bibliografske podrobnosti
izdano v:Cancer Immunol Res
Main Authors: Danilova, Ludmila, Ho, Won Jin, Zhu, Qingfeng, Vithayathil, Teena, De Jesus-Acosta, Ana, Azad, Nilofer S., Laheru, Daniel A., Fertig, Elana J., Anders, Robert, Jaffee, Elizabeth M., Yarchoan, Mark
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6548624/
https://ncbi.nlm.nih.gov/pubmed/31043417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-18-0822
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